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. 2022 Jul 11;10:886316. doi: 10.3389/fcell.2022.886316

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Copyright © 2022 Fallatah, Cui, Di Pietro, Carter, Pounder, Dorninger, Pifl, Moser, Berger and Braverman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pex7 genotype correlates with the myelin content in brain tissues from 12-month-old Pex7 deficient mice. Sagittal sections of brain tissues: corpus callosum (A–D) and cerebellum (E–H) show graded reduction in the levels of anti-MBP immunohistochemical staining in 12-month-old Pex7 deficient mice compared to their littermate controls. Slides were counterstained with hematoxylin (I, J) (Scale bar = 500 μm). Graded reduction in the amount of MBP protein levels was found in the immunoblot and densitometric analysis of cerebellar homogenates from Pex7 deficient mice at 12 months of age (K, L). (n = 3 per genotype).