Table 1.
Demographics and Baseline Characteristics of the Study Sample.
| Characteristic | Cefoxitin (n = 30) | Ertapenem (n = 55) | P value |
|---|---|---|---|
| Gender (%) | .11 | ||
| Female | 40 (12) | 58.1 (32) | |
| Age (mean ± SD) years | 68.03 ± 18.26 | 74.82 ± 12.798 | .049 |
| BMI (mean ± SD) | 28.58 ± 5.51 | 28.82 ± 6.76 | .87 |
| DM (%) | 63.33 (19) | 74.55 (41) | .28 |
| CAD (%) | 20 (6) | 18.18 (10) | .84 |
| Hypertension (%) | 53.33 (16) | 81.82 (45) | .0068 |
| Dyslipidemia (%) | 53.33 (16) | 60 (33) | .55 |
| Liver disease (%) | 13.33 (4) | 12.73 (7) | .94 |
| Cerebrovascular accident (%) | 36.67 (11) | 10.91 (6) | .0069 |
| COPD (%) | 10 (3) | 25.45 (14) | .1 |
| CHF (%) | 26.67 (8) | 21.82 (12) | .62 |
| Mechanically ventilated (%) | 13.33 (4) | 3.64 (2) | .12 |
| Renal function | .225 | ||
| Normal renal function (%) | 43 (13) | 50.9 (28) | |
| Acute kidney injury (%) | 13.3 (4) | 5.4 (3) | |
| Chronic kidney disease (%) | 30 (9) | 40 (22) | |
| Acute on of chronic kidney disease (%) | 10 (3) | 0.36 (2) | |
| End stage kidney disease (%) | 3.3 (1) | 0 | |
| Chronic respiratory failure (%) | 20 (6) | 7.27 (4) | .09 |
| Foley catheter at time of infection (%) | 63.3 (19) | 42 (23) | .077 |
| Organism in first culture | .686 | ||
| E. coli (%) | 56.6 (17) | 60 (33) | |
| Klebsiella spp. (%) | 43.3 (13) | 36.3 (20) | |
| Both E. coli and Klebsiella spp. (%) | 0 | 3.6 (2) | |
| Concomitant antibiotic (%) | 6.7 (2) | 0 | .122 |
| Charlson Comorbidity Index (mean ± SD) | 5.87 ± 2.56 | 6.53 ± 2.58 | .26 |
| Antibiotic dose in gram (mean ± SD) | 1.433 ± 0.5 | 1.01 ± 0.36 | NA |
| Frequency in hour (mean ± SD) | 9.73 ± 5.53 | 23.93 ± 4.25 | NA |
| WBC at therapy initiation × 109/L (mean ± SD) | 12.96 ± 5.17 | 11.32 ± 5.92 | .21 |
| Temperature at therapy initiation ℃ (mean ± SD) | 37.33 ± 0.73 | 37.32 ± 1.07 | .95 |
| CRP at therapy initiation in mg/L (mean ± SD) | 52.09 ± 59.86 | 87.79 ± 80.12 | .08 |
| Procalcitonin at therapy initiation in ng/mL (mean ± SD) | 0.1648 ± 0.16 | 0.19 ± 0.33 | .75 |
Note. BMI = Body Mass Index; CAD = coronary artery disease; CHF = congestive heart failure; COPD = chronic obstructive pulmonary disease; CRP = C-reactive protein; DM = diabetes mellitus.