Table 1:
Demographics and baseline features*
| All | MCI-CDR | Non-MCI- NC |
p value | MCI-NC | Non-MCI- NC |
p value | |
|---|---|---|---|---|---|---|---|
| n = 102 | n = 26 | n = 76 | n = 38 | n = 23 | |||
| Age | 65.1 (9.0) | 68.8 (8.7) | 63.8 (8.8) | 0.02 | 64.6 (8.6) | 65.9 (10.0) | 0.59 |
| Male sex | 76 (75) | 18 (69) | 58 (76) | 0.51 | 31 (82%) | 17 (74%) | 0.48 |
| MMSE | 28.0 (2.1) | 27.0 (2.3) | 28.4 (1.9) | 0.01 | 27.9 (1.9) | 28.8 (1.2) | 0.03 |
| Lawton IADL scale | 0.68 (2.5) | 1.9 (4.2) | 0.3 (1.3) | 0.07 | 1.0 (3.2) | 0.1 (0.6) | 0.10 |
| Charlson Comorbidity Index | 2.6 (1.7) | 2.8 (1.9) | 2.5 (1.6) | 0.51 | 2.7 (1.6) | 2.3 (1.9) | 0.39 |
| GAD score | 65.1 (9.0) | 5.7 (4.5) | 6.1 (5.3) | 0.75 | 6.0 (5.1) | 5.4 (3.8) | 0.59 |
| GDS score | 2.8 (2.5) | 3.2 (2.9) | 2.6 (2.3) | 0.39 | 2.9 (1.8) | 1.8 (1.2) | 0.03 |
| HRSD | 6.7 (5.6) | 7.0 (6.0) | 6.6 (5.5) | 0.77 | 6.7 (6.9) | 5.7 (3.3) | 0.43 |
| PHQ-9 | 5.3 (5.1) | 5.9 (5.3) | 5.1 (5.0) | 0.51 | 5.6 (5.6) | 4.4 (3.6) | 0.29 |
| Ethnicity | 0.84 | 0.72 | |||||
| Latino | 4 (4) | 1 (4) | 3 (4) | 1 (3) | 1 (4) | ||
| Non-Latino | 97 (95) | 25 (96) | 72 (95) | 37 (97) | 22 (96) | ||
| Race | 0.09 | 0.43 | |||||
| Native American | 1 (1) | 0 (0) | 1 (1) | 0 (0) | 1 (4) | ||
| Asian | 2 (2) | 0 (0) | 2 (3) | 1 (3) | 1 (4) | ||
| Black | 5 (5) | 4 (15) | 1 (1) | 3 (8) | 0 (0) | ||
| Pacific Islander | 1 (1) | 0 (0) | 1 (1) | 1 (3) | 0 (0) | ||
| White | 92 (90) | 22 (85) | 70 (92) | 32 (84) | 21 (91) | ||
| Mixed Race | 1 (1) | 0 | 1 (1) | 1 (3) | 0 (0) | ||
| Tobacco use history | 0.75 | 0.39 | |||||
| Non-smoker | 41 (40) | 10 (38) | 31 (41) | 17 (45) | 11 (48) | ||
| Current smoker | 12 (12) | 2 (8) | 10 (13) | 6 (16) | 1 (4) | ||
| Former smoker | 48 (47) | 14 (54) | 34 (45) | 15 (39) | 11 (48) | ||
| Alcohol | 0.76 | 0.03 | |||||
| Current | 39 (38) | 11 (42) | 28 (37) | 14 (37) | 15 (65) | ||
| No use | 62 (61) | 15 (58) | 47 (62) | 24 (63) | 8 (35) | ||
| Marital status | 0.14 | 0.41 | |||||
| Single | 18 (18) | 1 (4) | 17 (22) | 7 (18) | 2 (9) | ||
| Married | 56 (55) | 15 (58) | 41 (54) | 23 (61) | 17 (74) | ||
| Cohabiting | 2 (2) | 1 (4) | 1 (1) | 0 (0) | 0 (0) | ||
| Separated | 3 (3) | 2 (8) | 1 (1) | 0 (0) | 1 (4) | ||
| Divorced | 19 (19) | 5 (19) | 14 (18) | 7 (18) | 2 (9) | ||
| Widowed | 4 (4) | 2 (8) | 2 (3) | 1 (3) | 1 (4) | ||
| Education | 0.83 | 0.09 | |||||
| Grade school | 7 (7) | 2 (8) | 5 (7) | 2 (5) | 1 (4) | ||
| Some high school | 6 (6) | 2 (8) | 4 (5) | 3 (8) | 0 (0) | ||
| High school grad | 23 (23) | 6 (23) | 17 (22) | 7 (18) | 3 (13) | ||
| Vocational school | 8 (8) | 1 (4) | 7 (9) | 2 (5) | 0 (0) | ||
| Some college | 21 (21) | 7 (27) | 14 (18) | 7 (18) | 7 (30) | ||
| College graduate | 16 (16) | 3 (12) | 13 (17) | 10 (26) | 1 (4) | ||
| Some post-grad | 4 (4) | 0 (0) | 4 (5) | 2 (5) | 2 (9) | ||
| Post-grad degree | 17 (17) | 5 (19) | 12 (16) | 5 (13) | 9 (39) | ||
| Employment | 0.14 | 0.72 | |||||
| Retired | 43 (42) | 12 (46) | 31 (41) | 14 (37) | 10 (43) | ||
| Employed full-time | 37 (36) | 6 (23) | 31 (41) | 16 (42) | 10 (43) | ||
| Employed part-time | 8 (8) | 5 (19) | 3 (4) | 2 (5) | 2 (9) | ||
| Looking for work | 2 (2) | 0 (0) | 2 (3) | 2 (5) | 0 (0) | ||
| Not looking for work | 3 (3) | 1 (4) | 2 (3) | 2 (5) | 0 (0) | ||
| Disabled | 9 (9) | 2 (8) | 7 (9) | 2 (5) | 1 (4) | ||
| Income | 0.91 | 0.21 | |||||
| < $12k | 7 (7) | 1 (4) | 6 (8) | 2 (5) | 0 (0) | ||
| < $28.8k | 13 (13) | 3 (12) | 10 (13) | 6 (16) | 1 (4) | ||
| < $52.8k | 24 (24) | 8 (31) | 16 (21) | 11 (29) | 4 (17) | ||
| < 85k | 11 (11) | 2 (8) | 9 (12) | 2 (5) | 4 (17) | ||
| < $120k | 8 (8) | 2 (8) | 6 (8) | 4 (11) | 4 (17) | ||
| < $250k | 3 (3) | 1 4) | 2 (3) | 2 (5) | 0 (0) | ||
| $250k+ | 3 (3) | 0 (0) | 3 (4) | 0 (0) | 1 (4) |
*
Continuous variables: reported as mean (standard deviation), analyzed using independent t-test. Categorical variables: reported as n (%), analyzed using chi-square