Fig. 4.
Replication of GUSTO identified ppBMI and BW lipid signatures in Barwon Infant Study (BIS). A Sample collection at two time points. B PCA plot of lipidomics data (n=1935). C Association of pre-pregnancy BMI (ppBMI) with antenatal plasma lipidome. D Scatter plot of effect sizes in GUSTO and BIS for ppBMI study. E Association of birth weight (BW) with cord blood plasma lipidome. The most significant lipid species based on adjusted p-values are labeled in C and E. Effect sizes are shown as % change in lipid concentration per unit change in BMI, or per 100 g change in birth weight. Error bars indicate 95% confidence interval. Diamond—Padj ≥ 0.05 (gray), circle—Padj <0.05, and square—Padj <1.00E−5. F Scatter plot of effect sizes in GUSTO and BIS for BW study. Red—significant in both cohorts, purple—only significant in GUSTO, yellow—only significant in BIS, and gray—not significant in both cohorts