Table 3.

Phenotypes of osteoclastic lineage cells with modified STAT3 signaling pathway

Origin	Signaling pathway	Regulating factors	Effect on STAT3 (phosphorylation sites)	Downstream target gene	Phenotypes	Reference
RAW264.7cells and mice BMMs	STAT3/ RANKL	MSM	Decreased STAT3 phosphorylation at Ser727	NFATc1, TRAP, OSCAR, MMP9	Decreased cell viability and TRAP-positive multinucleated cells	[81]
RAW264.7cells and mice BMMs	STAT3, CD9/gp130/STAT3	WKYMVm	Decreased STAT3 phosphorylation at Ser727	NFATc1, c-Fos, MMP9, CTSK	Decreased TRAP-positive multinucleated cells	[82]
ST2 cells and mice BMMs	STAT3	HA	Decreased STAT3 phosphorylation	RANKL	Decreased TRAP-positive multinucleated cells	[97]
RAW264.7cells and mice BMMs	IL-34/STAT3/SMAD7	IL-34	Increased STAT3 phosphorylation	SMAD7	Increased TRAP-positive multinucleated cells	[86]
Mice bone marrow cells	STAT3	Heparin	Increased STAT3-DNA binding and transactivation at Ser727	gp130, RANKL	Increased TRAP-positive multinucleated cells	[93]
RAW264.7cells and BMMs	STAT3	PIAS3	Decreased DNA binding activity of STAT3	c-Fos, NFATc1, OSCAR, RANKL	Decreased TRAP-positive multinucleated cells	[90, 91]
Mice BMMs	STAT3	Niclosamide	Decreased STAT3 phosphorylation at Ser727	c-Fos, NFATc1, TRAP, OSCAR, av/b3 integrin, CTSK	Decreased TRAP-positive multinucleated cells	[95]
Mice BMMs	JAK3/STAT3	WHI-131	Increased STAT3 phosphorylation at Ser727	c-Fos, NFATc1	Decreased TRAP-positive multinucleated cells	[98]
Mice BMMs	STAT3	LIF	Increased STAT3 phosphorylation	CTSK, NFATc1, TRAP, Atp6a3, c-Fos	Increased TRAP-positive multinucleated cells	[108]