Figure 4. Feature selection by STG identifies genes that differentiate compartment (CSF or blood) and disease state (HIV or uninfected) with high accuracy.

(A) Accuracy plots for predicting HIV versus uninfected donor status of CSF or blood cells using the number of features shown on x axis. (B) Accuracy heatmaps for individual test pairs using a leave-two-out cross-validation. Green indicates that the disease state (HIV or uninfected) of the sample was ascertained with high accuracy using genes derived from the STG model. (C) Venn diagrams for genes that predict disease state in each compartment and cell type. (D) Ingenuity pathway analysis (IPA) of genes from C. n = 5 PWH and n = 4 uninfected controls.