Figure 3. Patients with breast cancer expressing high levels of gp78 are enriched in the pathways that drive the immune, stress, metabolic, cell cycle, and cell signaling pathways.

(A) GSEA using RNA-Seq differential expression data of patients stratified by high versus low gp78 expression (based on the median). (B) Overlap between gene sets enriched (FDR < 0.05) in patients stratified by gp78 expression and gene sets enriched in (FDR < 0.25) African American compared with European American patients with breast cancer. (C) Left, overlap between GSEA enrichment analysis (FDR < 0.05) based on gp78 protein stratification in African American (NHB) compared with European American (NHW) patients with breast cancer. Right, volcano plot of differential gene expression in patients median stratified by high versus low gp78 protein.