Figure 6. Gp78-derived gene modules predict pCR and cluster closely with established predictive gene signatures.

(A) Hierarchical clustering of patient scores based on gp78 modules and other predictive modules. (B) Volcano plot of patient gp78 gene modules scores and other gene signature scores in patients with residual versus pCR (log₂ residual disease/pCR). (C) Receiver operating curve comparison of regression analysis prediction of pCR using ROR (Prosigna) versus gp78 modules (MedcutW). See also Supplemental Figure 8.