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. 2022 Jul 8;7(13):e136678. doi: 10.1172/jci.insight.136678

Figure 13. MoDCs exhibit a reduction in proinflammatory gene expression with 2-HOBA treatment.

Figure 13

(A) Subclustering of myeloid cells with moDCs, cDC and cDCs/pDCs, monocytes, and macrophages represented. (B) Heatmap representing the top 5 markers for individual clusters. (C) Myeloid clusters represented as a percentage of total myeloid cells. (D) Myeloid clusters represented as percentage of total sequenced cells. (E) Volcano plot identifying differentially expressed genes in the moDC cluster between B6.SLE123+2-HOBA and B6.SLE123 mice. (F) Volcano plot identifying differentially expressed genes in the moDC cluster of B6.SLE123+2-HOBA and C57BL/6 control mice. (G) Gene ontology enrichment analysis of biological processes in the moDC cluster between B6.SLE123+2-HOBA and B6.SLE123. Violin plots representing the expression of proinflammatory genes (H) Il1b, (I) Fcgr4, (J) Cxcl14, (K) Coro1a, (L) Wfdc17, and (M) Pycard in the moDC cluster.