FIGURE 4.

Curcumin (Cur) suppressed Th17 cell response in DB mice with colitis. (a) Percentage of CD4⁺CCR6⁺ Th17 cells. (b) Percentage of CD4⁺IL‐17A⁺ Th17 cells. Statistical analysis of CD4⁺CCR6⁺ Th17 cells (c) and CD4⁺IL‐17A⁺ Th17 cells (d) among the Control, DSS, DSS + Cur, Con+Cur groups. (e) The concentration of IL‐17A in colonic tissue. (f) The mRNA levels of IL‐17A in colonic tissue. The mRNA levels of Th17 cells‐related nuclear transcription factors BATF (g), C‐Maf (h), RORγt (i) and RORɑ (j) in colon tissue. Data were presented as mean ± SEM (n = 8–11). * p < 0.05 and ** p < 0.01 compared to the Control group; ^# p < 0.05 and ^## p < 0.01 compared to the DSS group