Table 3 –

Overall sensitivity, specificity, PPV, and NPV of a change in MRI capturing pathologic progression.

	Progression endpoints	Sensitivity	Specificity	PPV	NPV
Change in MRI	GG1–≥GG2	0.53 (0.44–0.61)	0.64 (0.58–0.70)	0.38 (0.30–0.46)	0.76 (0.71–0.81)
	GG1–≥GG3	0.65 (0.50–0.80)	0.62 (0.56–0.67)	0.15 (0.10–0.21)	0.94 (0.91–0.97)
	GG2–≥GG3	0.67 (0.53–0.80)	0.59 (0.50–0.67)	0.32 (0.24–0.42)	0.86 (0.78–0.92)

GG = Gleason grade group; MRI = magnetic resonance imaging; NPV = negative predictive value; PPV = positive predictive value; PRECISE = Prostate Cancer Radiologic Estimation of Change in Sequential Evaluation.

A positive change in MRI is defined by a PRECISE score of ≥4, whereas negative/stable MRI is defined by a PRECISE score of <4.