Table 2.
Patient and kidney outcomes according to different AKI categories and AKD
| Mortality | ICU (n = 1286) |
P | Hospital (n = 1282) |
P | 30-day (n = 807) |
P |
|---|---|---|---|---|---|---|
| (a) Patient outcomes | ||||||
|
No AKI AKI |
12 (6.3%) 322 (29.4%) |
< 0.001 |
17 (8.9%) 350 (32.1%) |
< 0.001 |
11 (18.3%) 297 (37.3%) |
0.003 |
|
No AKI-sCr AKI-sCr |
108 (14.0%) 226 (43.8%) |
< 0.001 |
133 (17.3%) 234 (45.5%) |
< 0.001 |
95 (27.0%) 195 (42.9%) |
< 0.001 |
|
No AKI-UO AKI-UO |
33 (13.9%) 300 (28.7%) |
< 0.001 |
40 (16.9%) 326 (31.3%) |
< 0.001 |
28 (27.5%) 261 (37.2%) |
0.056 |
|
RR-AKI P-AKI |
23 (18.4%) 311 (26.8%) |
0.042 |
29 (23.2%) 338 (29.2%) |
0.158 |
22 (36.1%) 268 (35.9%) |
0.982 |
|
No AKD AKD |
9 (5.7%) 325 (28.8%) |
< 0.001 |
11 (6.9%) 356 (31.7%) |
< 0.001 |
8 (17.8%) 282 (37.0%) |
0.009 |
|
No KRT KRT |
263 (22.7%) 71 (56.3%) |
< 0.001 |
295 (25.5%) 72 (57.1%) |
< 0.001 |
232 (33.9%) 58 (47.5%) |
0.004 |
| Length of stay (days) | ||||||
|
All No AKI AKI |
11 (5.3, 22) 5 (2.8, 7.9) 12.1 (6.7, 24) |
< 0.001 |
18 (7, 34) 13.5 (6, 22) 19 (7, 36) |
< 0.001 | / | / |
| (b) Kidney outcomes | ||||||
| AKI | 1095/1286 (85.1%) | |||||
| ICU day start AKI (d) | 2 (1, 2) | |||||
| ICU day AKI max (d) | 2 (2, 4) | |||||
| Duration of AKI (d) | 5 (3, 9) | |||||
| RR-AKI | 125 (11.4%) | |||||
|
AKD (n = 1286) AKD–no AKI (n = 191) AKD–AKI (n = 1095) |
1127 (87.6%) 32 (2.8% of all AKD) 1095 (97.2% of all AKD) |
|||||
|
KRT (n = 1286) CKRT IHD |
126 (9.8%) 75 (59.5%) 51 (40.5%) |
|||||
| KRT start (d of ICU/date) | 7 (2, 12) | |||||
| KRT end (d of ICU/date) | 17 (10, 22) | |||||
| Duration KRT (d) (n = 96) | 8 (3, 14) | |||||
|
Kidney recovery (ICU survivors) AKI (n = 773) AKI-sCr (n = 290) AKI-UO (n = 740) AKI-UO excl KRT (n = 725) |
AKI-sCr vs AKI-UO: p < 0.001 369 (47.7%) 199 (68.6%) 407 (55.0%) 397 (54.8%) |
|||||
|
sCr@d21/ICU discharge (mg/dl) All ICU survivors (n = 952) No AKI (n = 179) AKI (n = 773) |
no AKI versus AKI p = 0.266 0.73 (0.61, 0.93) 0.70 (0.65, 0.90) 0.72 (0.60, 0.95) |
|||||
| KRT at 21 days or ICU discharge (n = 95) | 64 (67.4%) | |||||
AKI acute kidney injury, AKI-sCr AKI based on creatinine criteria only, AKI-UO AKI based on urine output criteria only, RR-AKI AKI with rapid reversal, P-AKI persistent AKI, AKD acute kidney disease, KRT kidney replacement therapy, CKRT continuous kidney replacement therapy, IHD intermittent hemodialysis, ICU intensive care unit, excl excluded, sCr serum creatinine, d day
Continuous variables are reported as median and interquartile ranges; categorical variables are reported as absolute numbers and frequencies