TABLE 2.
Frequency of patients with vital sign abnormalities
| Number of patients with episodes of vital sign abnormalities for 24 h (%) | |||
|---|---|---|---|
|
SAE during monitoring n = 70 |
SAE after monitoring n = 112 |
No SAE n = 309 |
|
| Respiratory vital sign abnormalities | |||
| SpO2 < 92% for ≥60 min | 32 (46%) | 59 (53%) | 160 (52%) |
| SpO2 < 88% for ≥10 min | 27 (39%) | 60 (54%) | 161 (52%) |
| SpO2 < 85% for ≥5 min | 25 (36%) | 49 (44%) | 135 (44%) |
| SpO2 < 80% for ≥1 min | 39 (56%) | 73 (65%) | 206 (67%) |
| RR < 5 min−1 for ≥1 min | 4 (5.7%) | 5 (4.5%) | 8 (2.6%) |
| RR < 11 min−1 for ≥5 min | 17 (24%) | 36 (32%) | 120 (39%) |
| RR > 24min−1 for ≥5 min | 15 (21%) | 17 (15%) | 38 (12%) |
| RR > 30 min−1 for ≥1 min | 12 (17%) | 8 (7.1%) | 32 (10%) |
| Circulatory vital sign abnormalities | |||
| HR < 30/min for ≥5 min | 3 (4.3%) | 5 (4.5%) | 6 (1.9%) |
| HR < 40/min for ≥5 min | 2 (2.9%) | 2 (1.8%) | 7 (2.3%) |
| HR > 110/min for ≥60 min | 11 (16%) | 8 (7.1%) | 12 (3.9%) |
| HR > 130/min for ≥30 min | 5 (7.1%) | 4 (3.6%) | 12 (3.9%) |
| SBP < 70 mm Hg ≥two times | 1 (1.4%) | 0 (0.0%) | 0 (0.0%) |
| SBP < 90 mm Hg ≥ two times | 8 (11%) | 19 (17%) | 29 (9.4%) |
| SBP > 180 mm Hg ≥ two times | 6 (8.6%) | 7 (6.2%) | 31 (10%) |
| SBP > 220 mm Hg ≥ two times | 0 (0.0%) | 1 (0.9%) | 1 (0.3%) |
Values are numbers (percentage). Data for patients with SAE during monitoring (n = 70) were analyzed for vital sign abnormalities in the 24 h preceding the first SAE. Data for patients with first SAE occurring after monitoring (n = 112) and patients without SAE (n = 309) were analyzed for vital sign abnormalities in 24 h, normalized from the entire monitoring period. Episodes of vital sign abnormalities are normalized to a 24 h period.; a patient with a vital sign abnormality less than one per 24 h will thus not be counted as having a vital sign abnormality. SpO2: Peripheral oxygen saturation, RR: Respiratory rate, HR: Heart rate SBP: Systolic blood pressure