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. 2022 Jul 11;13:935588. doi: 10.3389/fphar.2022.935588

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Copyright © 2022 Giacoletti, Price, Hoelz, Shremo Msdi, Cossin, Vazquez-Falto, Amorim Fernandes, Santos de Pontes, Wang, Boechat, Nornoo and Brust.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ST034307 plasma concentration peaks at 60 min after subcutaneous injection and reduces cAMP concentration in the DRG. (A) Plasma ST0304307 concentration versus time profile after a single 10 mg/kg subcutaneous injection in mice. N = 2,3. (B) A 10 mg/kg subcutaneous injection of ST034307 causes a reduction in cAMP concentration in the DRG of mice. DRG were dissected 90 min after injection. Data was normalized to respective matched vehicle-injected controls. N = 6. **p < 0.01 in one sample T test compared to 100%.