Table 2.

Laboratory tests performed in patients with neonatal erythroderma

	Deviation expected	Altered in specific diagnosis or in common NE	Reference(s)
Laboratory test in general
Sodium/potassium	↓↑	Common	1, 3, 4, 5, 7, 9
Serum albumin	↓	Common	1, 3, 4, 5, 7, 9
Complete blood count, leuco diff and platelets	↓↑	Common, NS, OS	1, 4, 9, 83, 97
Haemoglobin	↓	Common	5
Erythrocyte sedimentation rate	↑	Common	5
Serum creatinine and serum urea	↑	Common	7
C‐reactive protein	↑	Common	9
Laboratory test on indication
Capillary blood gas	ketoacidosis	Common	1
Natural Killer (NK‐) cells	↓	NS	98
Immunoglobulins IgE, IgG, and IgA	↓↑	NS, Omenn, AD, WAS, IPEX, IgA deficiency	12, 84, 97, 98
T and B lymphocytes	↓	PID	99, 100
Serum zinc and alkaline phosphatase	↓	Acrodermatitis enteropathica	97
Biotinidase and holocarboxylase essays	↓	Biotinidase and holocarboxylase deficiency	97
Serum tryptase	↑	Diffuse Cutaneous Mastocytosis	73, 101
Serum creatin kinase	↑	CDS	82
Ceruloplasmin and serum copper	↑	Menkes disease	43
Glucose	↓	Common	7, 9
Ammino acids (urine)	↑	NS	83
Serum ammonia	↑	Metabolic diseases	7, 9
Serum Calcium	↓	DiGeorge	102

AD, atopic dermatitis; CDS, Chanarin‐Dorfman syndrome; IPEX, Immunodysregulation polyendocrinopathy enteropathy X‐linked; NS, Netherton syndrome; OS, Omenn syndrome; PID, primary immunodeficiency; WAS, Wiskott‐Aldrich syndrome.