Figure 2.

Proteomics analysis focused on proteins involved in drug disposition (ADME (absorption, distribution, metabolism, and elimination)) in human jejunal and liver biopsies from 37 donors undergoing gastric bypass surgery. (a) Venn diagram of jejunal and liver proteins. (b) Correlation of proteins quantified in jejunal and liver biopsies (geometric mean protein levels from the donors). (c) Protein classes of drug disposition proteins specific to jejunum and liver, or overlapping proteins in the two tissues. (d) Protein levels of major drug‐metabolizing enzymes and transporting proteins in the jejunal and liver biopsies. Box plot displays median, 25th, and 75th percentile, and whiskers denote minimum and maximum values. Dots are displayed instead of box plot for proteins represented in fewer than 50% (n = 19) of the donors.