Table 1. Thirty-three immune-related DEGs that were common in the two comparisons.

Gene symbol	Gene description	Log2FC		Type
		Adult-juvenile	Geriatric-adult
HSPA1A	heat shock protein family A (Hsp70) member 1A	−4.65605793	2.267117457	Antigen Processing and Presentation
C8G	complement C8 gamma chain	−1.323993749	1.208984757	Antimicrobials
CLDN4	claudin 4	−2.239129897	3.148813288	Antimicrobials
JUND	JunD proto-oncogene, AP-1 transcription factor subunit	−1.439104566	1.564296492	Antimicrobials
LCN2	lipocalin 2	−1.076628541	2.11372877	Antimicrobials
NLRX1	NLR family member X1	−1.035408556	1.164222236	Antimicrobials
S100a7a	S100 calcium binding protein A7A	−1.958883689	2.373999596	Antimicrobials
SLC11A1	solute carrier family 11 member 1	−1.115382804	1.968902512	Antimicrobials
BLNK	B cell linker	−1.406416584	−1.1307455	BCR Signaling Pathway
CD72	CD72 molecule	−1.088614858	−1.733981295	BCR Signaling Pathway
IGHE	immunoglobulin heavy constant epsilon	2.954148316	−2.377432397	BCR Signaling Pathway
LILRB3	leukocyte immunoglobulin like receptor B3	−2.243575969	3.25109424	BCR Signaling Pathway
APLNR	apelin receptor	−4.326781357	4.650156681	Cytokine Receptors
CCR4	C-C motif chemokine receptor 4	1.644823712	−1.052058544	Cytokine Receptors
CX3CR1	C-X3-C motif chemokine receptor 1	1.713708318	−1.672821717	Cytokine Receptors
CXCR3	C − X − C motif chemokine receptor 3	1.303070848	1.105685341	Cytokine Receptors
FGFR3	fibroblast growth factor receptor 3	−1.728045213	2.931152467	Cytokine Receptors
IL4R	interleukin 4 receptor	−1.242601623	1.226363294	Cytokine Receptors
IL6R	interleukin 6 receptor	−1.172252092	1.423821312	Cytokine Receptors
PLXNA2	plexin A2	−1.903555435	−3.668139961	Cytokine Receptors
RXRA	retinoid X receptor alpha	−1.330663396	1.262262761	Cytokine Receptors
TNFRSF11A	TNF receptor superfamily member 11a	−1.335786001	2.560094347	Cytokine Receptors
BMP3	bone morphogenetic protein 3	3.739604433	3.60074447	cytokines
CAMP	cathelicidin antimicrobial peptide	−2.321472105	2.036598684	cytokines
GRN	granulin precursor	−1.004731552	1.655891229	cytokines
HDGF	heparin binding growth factor	−1.302057881	1.944179971	cytokines
OSGIN1	oxidative stress induced growth inhibitor 1	−1.367947542	2.399301935	cytokines
OSM	oncostatin M	−1.292596566	1.396710988	cytokines
PROK2	prokineticin 2	−1.174311847	2.229834977	cytokines
SEMA4B	semaphorin 4B	−1.066977692	1.364958783	cytokines
KLRC1	killer cell lectin like receptor C1	3.806902216	3.528593103	Natural Killer Cell
PAK4	p21 (RAC1) activated kinase 4	−1.430913333	1.28321432	TCR Signaling Pathway
VAV3	vav guanine nucleotide exchange factor 3	−1.035902369	1.208782905	TCR Signaling Pathway