TABLE 3.

Observational studies that described microdosing buprenorphine initiation for patients with OUD

Author, year	Sample size	Study type	BUP indication (%)	Inpatient, n (%)	Intervention	Starting BUP dose (mg)/day	Duration of initiation (days)	Withdrawal symptoms	Completed induction, n (%)	Post initiation outcome	Funding
27 Moe J, 2020 a	25	Feasibility study	OUD (100)	0 (0)	SL BUP	1 mg	6 days	NR	NR	32% of patients in the microdosing group remained on OAT at the 30‐day follow‐up	NR

Abbreviations: BUP, buprenorphine; NR, not reported; OAT, opioid agonist therapy; OUD, opioid use disorder.

^a Studies that compared traditional initiation to microdosing initiation. The traditional initiation method can be found in Table 2.