TABLE 3.
Predictors of first ADM episode duration amongst the IBD population
| ADM episode lasting <6 months | ADM episode lasting ≤28 days | |||
|---|---|---|---|---|
| Unadjusted OR (95% CI) | Adjusted OR (95% CI; P value) | Unadjusted OR (95% CI) | Adjusted OR (95% CI; P value) | |
| IBD Cohort | ||||
| UC | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| CD | 1.06 (0.87‐1.29) | 0.95 (0.77‐1.17; 0.621) | 1.05 (0.87‐1.29) | 1.42 (0.81‐1.25; 0.950) |
| Sex | ||||
| Male | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| Female | 0.96 (0.79‐1.16) | 0.97 (0.80‐1.17; 0.747) | 0.91 (0.75‐1.11) | 0.92 (0.76‐1.11; 0.393) |
| Age at diagnosis (years) | ||||
| <18 | 1.32 (0.77‐2.24) | 1.42 (0.81‐2.47; 0.220) | 1.20 (0.70‐2.06) | 1.27 (0.73‐2.21; 0.413) |
| 18 < 25 | 2.15 (1.52‐3.04) | 2.03 (1.40‐2.95; 0.000) | 1.91 (1.39‐2.60) | 2.03 (1.44‐2.84; 0.000) |
| 25 < 40 | 1.10 (0.86‐1.39) | 1.12 (0.88‐1.41; 0.349) | 1.11 (0.88‐1.43) | 1.12 (0.87‐1.43; 0.375) |
| 40 < 60 | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| ≥60 | 1.38 (1.07‐1.79) | 1.40 (1.07‐1.82; 0.012) | 1.50 (1.16‐1.94) | 1.47 (1.13‐1.92; 0.004) |
| Social deprivation | ||||
| IMD 1‐3 | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| IMD 4‐5 | 1.07 (1.01‐1.40) | 1.05 (0.80‐1.38; 0.739) | 1.40 (1.07‐1.82) | 1.40 (1.07‐1.83; 0.013) |
| Unknown | 0.81 (0.65‐0.99) | 0.79 (0.64‐0.98; 0.033) | 0.98 (0.75‐1.15) | 0.94 (0.76‐1.17; 0.576) |
| Era of IBD diagnosis | ||||
| Era 1 2004‐2007 | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| Era 2 2008‐2011 | 1.06 (0.86‐1.32) | 1.07 (0.86‐1.33; 0.533) | 1.06 (0.85‐1.31) | 1.04 (0.83‐1.30; 0.744) |
| Era 3 2012‐2015 | 1.10 (0.84‐1.37) | 1.07 (0.84‐1.37; 0.584) | 0.97 (0.76‐1.24) | 0.96 (0.75‐1.24; 0.762) |
| Smoking status | ||||
| Never | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| Smoker | 1.81 (0.62‐1.06) | 1.06 (0.80‐1.41; 0.654) | 1.14 (0.92‐1.42) | 1.17 (0.88‐1.55; 0.229) |
| Ex‐smoker | 0.98 (0.74‐1.29) | 0.85 (0.66‐1.09; 0.214) | 1.21 (0.92‐1.59) | 1.19 (0.90‐1.57; 0.891) |
| Missing | 0.80 (0.59‐1.07) | 0.86 (0.65‐1.14; 0.311) | 0.91 (0.67‐1.24) | 0.96 (0.70‐1.32; 0.151) |
| Corticosteroid use | ||||
| No | 1 (‐) | 1 (‐) | 1 (‐) | 1 (‐) |
| Yes | 1.24 (0.83‐1.85) | 1.19 (0.79‐1.78; 0.409) | 1.00 (0.66‐1.51) | 0.96 (0.63‐1.46; 0.874) |
All covariates described were included within the adjusted analysis. Abbreviations: HR, Hazard ratio; CI, confidence interval; *IBD, inflammatory bowel disease; *IMD ‐ Index of Multiple Deprivation; IMD 1 represents the least deprived and IMD 5 the most deprived. IMD ‐ Data are available only for individual’s resident in England.
Bold values indicate statistical significance.