TABLE 2.
Summary of demographics and study design difference between studies selected for meta‐analyses
| Studies with OR outcome | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Author | Year/country | Study design | Study population | Type of invasive dental procedure | Study duration | Adjustment of confounders | Outcome reported OR | ||||
| Age (years) | Gender | Control group | No. of subjects | ||||||||
| Male | Female | ||||||||||
| Type of event, MI | |||||||||||
| Chen et al |
2019 Taiwan |
Case crossover | 20 to ≥90 | 83,752 (67.6%) | 40,067 (32.4%) | Burn patients |
MI = 123,819 Burns = 73,247 |
SRP Dentoalveolar surgery/tooth extractions Odentectomy Periodontal surgery |
24 weeks |
Diabetes Hypertension Hyperlipidaemia Congestive heart failure Age Sex |
3 days = 1.05; 95% CI: 1.08–1.58 7 days = 1.00; 95% CI: 1.01–1.31 2 weeks = 1.02; 95% CI: 0.96–1.08 4 weeks = 0.99; 95% CI: 0.94–1.04 8 weeks = 0.98; 95% CI: 0.95–1.02 |
| Nordendahl et al |
2018 Sweden |
Case–control study |
Case = 72.6 ± 13 Controls = 72.3 ± 13 |
Cases = 32,107 (62%) Controls = 151,636 (61%) |
Cases = 19,773 (38%) Controls = 95,342 (39%) |
5 control subjects—randomly selected, free from prior MI matched for age, sex, and geographic area of residence. |
MI = 51,880 Controls = 246,978 |
SRP Dentoalveolar surgery/tooth extractions Implant surgery Periodontal surgery Apical surgery |
4 weeks |
Diabetes Previous CVD CVD Drugs Education Income Age Sex Geographic area |
2 days =0.71; 95% CI: 0.55–0.93 2 weeks = 0.92; 95% CI: 0.83–1.02 4 weeks = 0.98; 95% CI: 0.91–1.06 |
| Type of event, IS | |||||||||||
| Chen et al |
2019 Taiwan |
Case crossover | 20 to ≥90 | 189,659 (58%) | 137,520 (42%) | Burn patients |
IS = 327,179 Burns = 73,247 |
SRP Dentoalveolar surgery/tooth extractions Odentectomy Periodontal surgery |
24 weeks |
Diabetes Hypertension Hyperlipidaemia Congestive heart failure Age Sex |
3 days = 0.93; 95% CI: 0.86–1.01 7 days = 0.97; 95% CI: 0.92–1.02 2 weeks = 0.97; 95% CI: 0.93–1.01 4 weeks = 0.97; 95% CI: 0.94–1.00 8 weeks = 0.97; 95% CI: 0.95–0.99 |
| Studies with IR outcome | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Author | Year/country | Study design | Study population | Type of invasive dental procedure | Study duration | Adjustment of confounders | Outcome reported IR | |||
| Age (years) | Gender (WP/IP) | No. of subjects | ||||||||
| Male | Female | |||||||||
| Type of event, MI | ||||||||||
| Chen et al | 2019 | Self‐controlled case series | 20 to ≥90 | 84,448 (71.8%) | 33,207 (28.2%) | MI = 117,655 |
SRP Dentoalveolar surgery/tooth extractions Odentectomy Periodontal surgery |
24 weeks |
Diabetes Hypertension Hyperlipidaemia Congestive heart failure Age Sex |
1–3 days = 1.05; 95% CI: 0.98–1.13 4–7 days = 1.02; 95% CI: 0.95–1.08 8–14 days = 1.00; 95% CI: 0.95–1.06 3–4 weeks = 0.94; 95% CI: 0.91–0.98 5–8 weeks = 1.01; 95% CI: 0.98–1.04 |
| Minassian et al | 2010 | Self‐controlled case series | 20 to ≥90 | 236 (45%) | 289 (55.1%) | MI = 525 |
SRP Dentoalveolar surgery/tooth extractions Implant surgery Periodontal surgery Apical surgery |
24 weeks | Age |
1–4 weeks = 1.56; 95% CI: 0.98–2.47 5–8 weeks = 1.35; 95% CI: 0.82–2.23 |
| Type of event, IS | ||||||||||
| Chen et al | 2019 | Self‐controlled case series | 177,175 (59.3%) | 121,582 (40.7%) | IS = 298,757 |
SRP Dentoalveolar surgery/tooth extractions Odentectomy Periodontal surgery |
24 weeks |
Diabetes Hypertension Hyperlipidaemia Congestive heart failure Age Sex |
1–3 days = 0.94; 95% CI: 0.90–0.99 4–7 days = 1.06; 95% CI: 1.01–1.10 8–14 days = 1.05; 95% CI: 1.01–1.08 3–4 weeks = 1.05; 95% CI: 1.02–1.07 5–8 weeks = 1.05; 95% CI: 1.03–1.07 |
|
| Minassian et al | 2010 | Self‐controlled case series | 20 to ≥90 | 233 (35.9%) | 417 (64.2%) | IS = 650 |
SRP Dentoalveolar surgery/tooth extractions Implant surgery Periodontal surgery Apical surgery |
24 weeks | Age |
1–4 weeks = 1.39; 95% CI: 0.89–2.15 5–8 weeks = 0.94; 95% CI: 0.55–1.60 |
Abbreviations: CI, confidence interval; CVD, cardiovascular disease; IP, incident population; IS, ischaemic stroke; MI, myocardial infarction; OR, odds ratio; SRP, scaling and root planing; WP, whole population.