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. 2022 Jul 25;2022(7):CD012369. doi: 10.1002/14651858.CD012369.pub2
Source Search strategy Hits retrieved
VASCULAR REGISTER IN CRSW
(Date of most recent search: 7 December 2021)		 #1 DVT AND INREGISTER AND 01/01/2017_TO_19/12/2018:CRSINCENTRAL
#2 deep vein thrombosis AND INREGISTER AND 01/01/2017_TO_19/12/2018:CRSINCENTRAL
#3 #1 OR #12
#4 antiplatelet OR aspirin AND INREGISTER AND 01/01/2017_TO_19/12/2018:CRSINCENTRAL
#5 #13 AND #4		 Dec 2018: 5
Dec 2021: 21
CENTRAL via CRSO
(Date of most recent search: 7 December 2021)		 #1 MESH DESCRIPTOR Thrombosis 1640
#2 MESH DESCRIPTOR Thromboembolism 1139
#3 MESH DESCRIPTOR Venous Thromboembolism 473
#4 MESH DESCRIPTOR Venous Thrombosis EXPLODE ALL TREES 2403
#5 thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol* 26461
#6 MESH DESCRIPTOR Pulmonary Embolism EXPLODE ALL TREES 886
#7 (PE or DVT or VTE):TI,AB,KY 6517
#8 ((vein* or ven*) near thromb*):TI,AB,KY 8177
#9 (blood near3 clot*):TI,AB,KY 4047
#10 (lung near3 clot*):TI,AB,KY 7
#11 (pulmonary near3 clot*):TI,AB,KY 9
#12 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 33538
#13 MESH DESCRIPTOR Platelet Aggregation Inhibitors EXPLODE ALL TREES 10011
#14 MESH DESCRIPTOR Phosphodiesterase Inhibitors EXPLODE ALL TREES 6569
#15 MESH DESCRIPTOR Tetrazoles 1962
#16 (antiplatelet* or anti‐platelet* or antiaggreg* or anti‐aggreg*):TI,AB,KY 4672
#17 ((platelet or thromboxane or thrombocyte or cyclooxygenase or cyclo‐oxygenase or phosphodiesterase or fibrinogen or PAR‐1) near3 (antagonist or inhibitor)):TI,AB,KY 2786
#18 ((gp* or glycoprotein* or protease or P2Y12 or TXA2) near3 inhibit*):TI,AB,KY 3914
#19 thienopyridine:TI,AB,KY 340
#20 (ticlopidine or Ticlid):TI,AB,KY 2256
#21 (clopidogrel or Plavix):TI,AB,KY 4284
#22 (Prasugrel or Effient or Efient or Prasita):TI,AB,KY 836
#23 (ticagrelor or AZD6140 or Brilinta):TI,AB,KY 1061
#24 (elinogrel or PRT060128 or PRT‐060128):TI,AB,KY 8
#25 (cangrelor or AR‐C6993* or ARC6993*):TI,AB,KY 89
#26 (SCH530348 or SCH‐530348):TI,AB,KY 20
#27 E5555:TI,AB,KY 9
#28 (terutroban or Triplion):TI,AB,KY 19
#29 (aspirin* or nitroaspirin or ASA):TI,AB,KY 20443
#30 (acetylsalicylic acid):TI,AB,KY 6269
#31 (acetyl salicylic acid*):TI,AB,KY 126
#32 (triflusal or disgren):TI,AB,KY 107
#33 (Cilostazol or Pletal or Pletaal):TI,AB,KY 626
#34 (dipyridamol* or Persantine):TI,AB,KY 1236
#35 (OPC‐13013 or OPC13013):TI,AB,KY 5
#36 (picotamide or picotinamide):TI,AB,KY 41
#37 satigrel:TI,AB,KY 3
#38 vorapaxar:TI,AB,KY 115
#39 indobufen:TI,AB,KY 82
#40 abciximab:TI,AB,KY 739
#41 tirofiban:TI,AB,KY 454
#42 #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 26746
#43 OR#40 OR #41 454
#44 #12 AND #42 4060		 Dec 2018: 1024
Dec 2021: 1613
ClinicalTrials.gov
(Date of most recent search: 7 December 2021)		 antiplatelet OR aspirin | deep vein thrombosis Dec 2018: 3
Dec 2021: 2
ICTRP Search Portal
(Date of most recent search: 7 December 2021)		 antiplatelet OR aspirin | deep vein thrombosis Dec 2018: 5
Dec 2021: 9
MEDLINE (Ovid MEDLINE Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE Daily and Ovid MEDLINE) 1946 to present
(Date of most recent search: 7 December 2021)		 1 THROMBOSIS/
2 THROMBOEMBOLISM/
3 Venous Thromboembolism/
4 exp Venous Thrombosis/
5 (thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*).ti,ab.
6 exp Pulmonary Embolism/
7 (PE or DVT or VTE).ti,ab.
8 ((vein* or ven*) adj thromb*).ti,ab.
9 (blood adj3 clot*).ti,ab.
10 (pulmonary adj3 clot*).ti,ab.
11 (lung adj3 clot*).ti,ab.
12 or/1‐11
13 exp Platelet Aggregation Inhibitors/
14 exp Phosphodiesterase Inhibitors/
15 exp TETRAZOLES/
16 (antiplatelet* or anti‐platelet* or antiaggreg* or anti‐aggreg*).ti,ab.
17 ((platelet or thromboxane or thrombocyte or cyclooxygenase or cyclo‐oxygenase or phosphodiesterase or fibrinogen or PAR‐1) adj3 (antagonist or inhibitor)).ti,ab.
18 ((gp* or glycoprotein* or protease or P2Y12 or TXA2) adj3 inhibit*).ti,ab.
19 thienopyridine.ti,ab.
20 (ticlopidine or Ticlid).ti,ab.
21 (clopidogrel or Plavix).ti,ab.
22 (Prasugrel or Effient or Efient or Prasita).ti,ab.
23 (ticagrelor or AZD6140 or Brilinta).ti,ab.
24 (elinogrel or PRT060128 or PRT‐060128).ti,ab.
25 (cangrelor or AR‐C6993* or ARC6993*).ti,ab.
26 (SCH530348 or SCH‐530348).ti,ab.
27 E5555.ti,ab.
28 (terutroban or Triplion).ti,ab.
29 (aspirin* or nitroaspirin or ASA).ti,ab.
30 acetylsalicylic acid.ti,ab.
31 acetyl salicylic acid*.ti,ab.
32 (triflusal or disgren).ti,ab.
33 (Cilostazol or Pletal or Pletaal).ti,ab.
34 (dipyridamol* or Persantine).ti,ab.
35 (OPC‐13013 or OPC13013).ti,ab.
36 (picotamide or picotinamide).ti,ab.
37 satigrel.ti,ab.
38 vorapaxar.ti,ab.
39 indobufen.ti,ab.
40 abciximab.ti,ab.
41 tirofiban.ti,ab.
42 or/13‐41
43 12 and 42
44 randomized controlled trial.pt.
45 controlled clinical trial.pt.
46 randomized.ab.
47 placebo.ab.
48 drug therapy.fs.
49 randomly.ab.
50 trial.ab.
51 groups.ab.
52 or/44‐51
53 exp animals/ not humans.sh.
54 52 not 53
55 43 and 54		 Dec 2018: 1157
Dec 2021: 2549
Embase via Ovid
(Date of most recent search: 7 December 2021)		 1 thrombosis/
2 thromboembolism/
3 venous thromboembolism/
4 exp vein thrombosis/
5 (thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*).ti,ab.
6 exp lung embolism/
7 (PE or DVT or VTE).ti,ab.
8 ((vein* or ven*) adj thromb*).ti,ab.
9 (blood adj3 clot*).ti,ab.
10 (pulmonary adj3 clot*).ti,ab.
11 (lung adj3 clot*).ti,ab.
12 or/1‐11
13 exp antithrombocytic agent/
14 exp phosphodiesterase inhibitor/
15 tetrazole derivative/
16 (antiplatelet* or anti‐platelet* or antiaggreg* or anti‐aggreg*).ti,ab.
17 ((platelet or thromboxane or thrombocyte or cyclooxygenase or cyclo‐oxygenase or phosphodiesterase or fibrinogen or PAR‐1) adj3 (antagonist or inhibitor)).ti,ab.
18 ((gp* or glycoprotein* or protease or P2Y12 or TXA2) adj3 inhibit*).ti,ab.
19 thienopyridine.ti,ab.
20 (ticlopidine or Ticlid).ti,ab.
21 (clopidogrel or Plavix).ti,ab.
22 (Prasugrel or Effient or Efient or Prasita).ti,ab.
23 (ticagrelor or AZD6140 or Brilinta).ti,ab.
24 (elinogrel or PRT060128 or PRT‐060128).ti,ab.
25 (cangrelor or AR‐C6993* or ARC6993*).ti,ab.
26 (SCH530348 or SCH‐530348).ti,ab.
27 E5555.ti,ab.
28 (terutroban or Triplion).ti,ab.
29 (aspirin* or nitroaspirin or ASA).ti,ab.
30 acetylsalicylic acid.ti,ab.
31 acetyl salicylic acid*.ti,ab.
32 (triflusal or disgren).ti,ab.
33 (Cilostazol or Pletal or Pletaal).ti,ab.
34 (dipyridamol* or Persantine).ti,ab.
35 (OPC‐13013 or OPC13013).ti,ab.
36 (picotamide or picotinamide).ti,ab.
37 satigrel.ti,ab.
38 vorapaxar.ti,ab.
39 indobufen.ti,ab.
40 abciximab.ti,ab.
41 tirofiban.ti,ab.
42 or/13‐41
43 12 and 42
44 randomized controlled trial/
45 controlled clinical trial/
46 random$.ti,ab.
47 randomization/
48 intermethod comparison/
49 placebo.ti,ab.
50 (compare or compared or comparison).ti.
51 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab.
52 (open adj label).ti,ab.
53 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab.
54 double blind procedure/
55 parallel group$1.ti,ab.
56 (crossover or cross over).ti,ab.
57 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab.
58 (assigned or allocated).ti,ab.
59 (controlled adj7 (study or design or trial)).ti,ab.
60 (volunteer or volunteers).ti,ab.
61 trial.ti.
62 or/44‐61
63 43 and 62		 Dec 2018: 3148
Dec 2021: 5234
CINAHL via Ebsco
(Date of most recent search: 7 December 2021)		 S55 S42 AND S54
S54 S43 OR S44 OR S45 OR S46 OR S47 OR S48 OR S49 OR S50 OR S51 OR S52 OR S53
S53 MH "Random Assignment"
S52 MH "Single‐Blind Studies" or MH "Double‐Blind Studies" or MH "Triple‐Blind Studies"
S51 MH "Crossover Design"
S50 MH "Factorial Design"
S49 MH "Placebos"
S48 MH "Clinical Trials"
S47 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study"
S46 TX crossover OR "cross‐over"
S45 AB placebo*
S44 TX random*
S43 TX "latin square"
S42 S12 AND S41
S41 S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40
S40 TX tirofiban
S39 TX abciximab
S38 TX indobufen
S37 TX vorapaxar
S36 TX satigrel
S35 TX picotamide or picotinamide
S34 TX OPC‐13013 or OPC13013
S33 TX dipyridamol* or Persantine
S32 TX Cilostazol or Pletal or Pletaal
S31 TX triflusal or disgren
S30 TX acetyl salicylic acid*
S29 TX acetylsalicylic acid
S28 TX aspirin* or nitroaspirin or ASA
S27 TX terutroban or Triplion
S26 TX E5555
S25 TX SCH530348 or SCH‐530348
S24 TX cangrelor or AR‐C6993* or ARC6993*
S23 TX elinogrel or PRT060128 or PRT‐060128
S22 TX ticagrelor or AZD6140 or Brilinta
S21 TX Prasugrel or Effient or Efient or Prasita
S20 TX clopidogrel or Plavix
S19 TX ticlopidine or Ticlid
S18 TX thienopyridine
S17 TX (gp* or glycoprotein* or protease or P2Y12 or TXA2) n3 inhibit*)
S16 TX (platelet or thromboxane or thrombocyte or cyclooxygenase or cyclo‐oxygenase or phosphodiesterase or fibrinogen or PAR‐1) n3 (antagonist or inhibitor)
S15 TX antiplatelet* or anti‐platelet* or antiaggreg* or anti‐aggreg*
S14 MH "Phosphodiesterase Inhibitors+"
S13 MH "Platelet Aggregation Inhibitors+"
S12 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11
S11 TX lung n3 clot*
S10 TX pulmonary n3 clot*
S9 TX blood n3 clot*
S8 TX ((vein* or ven*) n thromb*)
S7 TX PE or DVT or VTE
S6 MH "Pulmonary Embolism"
S5 TX thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*
S4 MH "Venous Thrombosis+"
S3 MH "Venous Thromboembolism"
S2 MH "Thromboembolism"
S1 MH "Thrombosis"		 Dec 2018: 197
Dec 2021: 413
AMED via Ovid
(Date of most recent search: 7 December 2021)		 1 thrombosis/
2 thromboembolism/
3 venous thromboembolism/
4 exp vein thrombosis/
5 (thrombus* or thrombopro* or thrombotic* or thrombolic* or thromboemboli* or thrombos* or embol*).ti,ab.
6 exp lung embolism/
7 (PE or DVT or VTE).ti,ab.
8 ((vein* or ven*) adj thromb*).ti,ab.
9 (blood adj3 clot*).ti,ab.
10 (pulmonary adj3 clot*).ti,ab.
11 (lung adj3 clot*).ti,ab.
12 or/1‐11
13 (antiplatelet* or anti‐platelet* or antiaggreg* or anti‐aggreg*).ti,ab.
14 ((platelet or thromboxane or thrombocyte or cyclooxygenase or cyclo‐oxygenase or phosphodiesterase or fibrinogen or PAR‐1) adj3 (antagonist or inhibitor)).ti,ab.
15 ((gp* or glycoprotein* or protease or P2Y12 or TXA2) adj3 inhibit*).ti,ab.
16 thienopyridine.ti,ab.
17 (ticlopidine or Ticlid).ti,ab.
18 (clopidogrel or Plavix).ti,ab.
19 (Prasugrel or Effient or Efient or Prasita).ti,ab.
20 (ticagrelor or AZD6140 or Brilinta).ti,ab.
21 (elinogrel or PRT060128 or PRT‐060128).ti,ab.
22 (cangrelor or AR‐C6993* or ARC6993*).ti,ab.
23 (SCH530348 or SCH‐530348).ti,ab.
24 E5555.ti,ab.
25 (terutroban or Triplion).ti,ab.
26 (aspirin* or nitroaspirin or ASA).ti,ab.
27 acetylsalicylic acid.ti,ab.
28 acetyl salicylic acid*.ti,ab.
29 (triflusal or disgren).ti,ab.
30 (Cilostazol or Pletal or Pletaal).ti,ab.
31 (dipyridamol* or Persantine).ti,ab.
32 (OPC‐13013 or OPC13013).ti,ab.
33 (picotamide or picotinamide).ti,ab.
34 satigrel.ti,ab.
35 vorapaxar.ti,ab.
36 indobufen.ti,ab.
37 abciximab.ti,ab.
38 tirofiban.ti,ab.
39 or/13‐38
40 12 and 39
41 exp CLINICAL TRIALS/
42 RANDOM ALLOCATION/
43 DOUBLE BLIND METHOD/
44 Clinical trial.pt.
45 (clinic* adj trial*).tw.
46 ((singl* or doubl* or trebl* or tripl*) adj (blind* or mask*)).tw.
47 PLACEBOS/
48 placebo*.tw.
49 random*.tw.
50 PROSPECTIVE STUDIES/
51 or/41‐50
52 40 and 51		 Dec 2018: 0
Dec 2021: 2
TOTAL before deduplication   Dec 2018: 5539
Dec 2021: 9843
TOTAL after deduplication   Dec 2018: 4353
Dec 2021: 7864