Table 3:
Shown are the protein names, N-terminal sequence of the mature protein, the penultimate residue that would be recognized and cleaved by DPP4, and the basic molecular function of the protein, as annotated by Uniprot. The final column indicates whether there are multiple truncation sites available to DPP4. What YES indicates is that after the first truncation, there is another putative DPP4 site remaining on the truncated protein that may be cleaved again. Additional cleavages of the protein may further alter the functions of these molecules, and there may be differences in the function of a singly truncated protein versus a doubly (triply, etc.) truncated peptide. YES *(Serine) indicates that the protein has a second putative DPP4 truncation site, but that this second site is a Serine residue, for which DPP4 has a lower affinity.
| Protein | Description | N-term sequence | Penultimate AA (substrate) | Multiple truncation sites? |
|---|---|---|---|---|
|
| ||||
| ATF7IP2 | Histone methyltransferase cofactor | MASPDR | A | YES |
| BCL2/BAD | Pro-apoptotic factor | MAHAGR | A | YES |
| BCL2L13 | Pro-apoptotic factor | MASSST | A | YES(*Serine) |
| BCL3 | Anti-apoptotic factor | M PRC PA | P | NO |
| BCL6 | Anti-apoptotic factor | MASPAD | A | YES |
| BEX3 | Pro-apoptotic factor | MANIHQ | A | NO |
| EHMT1 | Histone methyltransferase | AAADAE | A | NO |
| EHMT2 | Histone methyltransferase | AAAAGA | A | YES |
| HDAC1 | Histone deacetylase | MAQTQG | A | NO |
| HDAC2 | Histone deacetylase | MAYSQG | A | YES(*Serine) |
| HDAC3 | Histone deacetylase | MAKTVA | A | NO |
| KDM1B | Histone demethylase | MATPRG | A | YES |
| KDM2B | Histone demethylase | MAGPQM | A | YES |
| KDM5A | Histone demethylase | MAGVGP | A | NO |
| KDM7A | Histone demethylase | MAGAAA | A | YES |
| KDM8 | Histone demethylase | MAGDTH | A | NO |
| P0LA1 | DNA polymerase component | MAPVHG | A | NO |
| P0LE2 | DNA polymerase component | MAPERL | A | NO |
| P0LE4 | DNA polymerase component | AAAAAA | A | YES |
| POLH | DNA polymerase component | MATGQD | A | NO |
| P0LR1C | RNA polymerase I component | AASQAV | A | NO |
| P0LR1E | RNA polymerase I component | MAAEVL | A | NO |
| POLR2D | RNA polymerase II component | MAAGGS | A | NO |
| POLR3E | RNA polymerase III component | MANEED | A | NO |
| POLR3G | RNA polymerase III component | MAGNKG | A | NO |
| POLR3GL | RNA polymerase III component | MASRGG | A | NO |
| SET | Transcription factor | APKRQS | P | NO |
| SETD6 | Histone methyltransferase | MATQAK | A | NO |
| SUV39H1 | Histone methyltransferase | MAENLK | A | NO |
| SUV39H2 | Histone methyltransferase | MAAVGA | A | NO |
| TMPO | Thymopoeitin | MPEFLE | P | NO |
| ZNF16 | Zinc fingertranscriptional regulator | MPSLRT | P | NO |
| ZNF268 | Zinc fingertranscriptional regulator | MATRVR | A | NO |
| ZNF91 | Zinc fingertranscriptional regulator | MPGTPG | P | NO |