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. 2022 Jul 22;19(1):943–960. doi: 10.1080/15476286.2022.2100971

Figure 5.

Figure 5.

U1 snRNA SL3 and SL4 are targeted by splicing factors to modulate 5’-splice site (5ʹss) recognition and spliceosome assembly. (a) Protein cross-links to U1 snRNA in vivo [98,99]. The heat map shows the distribution of cross-links to U1 snRNA for 147 RNA-binding proteins. (b) Solution structure of FUS-RRM (blue) in complex with U1 snRNA SL3 (grey) (pdb code: 6SNJ) [101]. The structure corresponds to the lowest energy model from the NMR ensemble. (c) Model for exon independent recruitment of SRSF1 by U1 snRNP [98]. (d) Model for UAP56 mediated splicing enhancement [100]. (e) Crystal structure of SF3A1-UBL (cyan) in complex with U1 snRNA SL4 (grey) (pdb code: 7P0V) [108]. (f) Model for PTB mediated splicing repression [110,111].