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. 2022 Jun 16;42(8):1005–1022. doi: 10.1161/ATVBAHA.121.317451

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© 2022 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 5. — Smooth muscle cell (SMC) modulation driven by hypercholesterolemia in mice occurs through 2 lineages, one of which is dependent on Perk signaling. A, Relative location of contractile SMC (cSMC), mSMC1, and mSMC2 cells among the various cell clusters. B, Distribution of contractile SMCs (gray), mSMC1 (red), and mSMC2 (pink) along different trajectories. C, Distribution of the pseudotime trajectories within each lineage highlights the differences among the 3 groups of SMCs. D and E, Modules of genes that have a similar pattern of expression through the lineage trajectory 1 (D) and trajectory 2 (E). F and G, Transcription factors affected by Perk enriched in lineages 1 (F) and 2 (G). HFD indicates hypercholesterolemia followed by high-fat diet.