Table 4.
Effect of RV (mg/L) on CHX and BZK MIC (mg/L) and MBC (MFC in the case of Candida spp.) (mg/L) in combination against Gram-negative bacteria, Gram-positive bacteria and yeasts.
| Strain | CHX MIC (MBC or MFC) |
BZK MIC (MBC or MFC) |
0 RV | FIC * Index (a) |
32 RV | FIC * Index (b) | 64 RV | FIC * Index (c) |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CHX + BZK MIC (MBC or MFC) |
CHX + BZK MIC (MBC or MFC) |
CHX + BZK MIC (MBC or MFC) |
|||||||||
|
A. baumannii ATCC 19606 |
32 (32) | 16 (16) | 8 (8) | 4 (4) | 0.5 | 2 (2) | 2 (2) | 0.187 | 2 (2) | 0.5 (0.5) | 0.093 |
|
A. baumannii ∆adeB ATCC 19606 |
4 (4) | 8 (8) | 1 (1) | 2 (2) | 0.5 | 2 (2) | 0.06 (0.06) | 0.50 | 0.5 (0.5) | 0.5 (0.5) | 0.18 |
|
A. baumannii ACICU |
64 (128) | 16 (32) | 8 (8) | 2 (2) | 0.25 | 2 (2) | 0.5 (0.5) | 0.062 | 2 (2) | 0.5 (0.5) | 0.062 |
|
B. cenocepacia LMG 16654 |
64 (64) | 64 (64) | 8 (8) | 2 (2) | 0.15 | 8 (8) | 2 (2) | 0.15 | 8 (8) | 0.5 (0.5) | 0.13 |
|
B. dolosa LMG 21443 |
16 (16) | 8 (8) | 4 (8) | 2 (2) | 0.31 | 4 (4) | 1 (1) | 0.28 | 4 (4) | 0.5 (0.5) | 0.26 |
|
B. multivorans LMG16665 |
64 (64) | 32 (64) | 8 (8) | 8 (8) | 0.25 | 8 (8) | 8 (8) | 0.25 | 8 (8) | 0.5 (0.5) | 0.13 |
|
E. cloacae ATCC 13047 |
8 (8) | 8 (8) | 2 (2) | 4 (4) | 0.5 | 2 (2) | 4 (4) | 0.5 | 2 (2) | 2 (2) | 0.375 |
|
K. pneumoniae ATCC 700603 |
128 (128) | 16 (16) | 16 (32) | 4 (4) | 0.25 | 4 (4) | 2 (2) | 0.093 | 4 (4) | 2 (2) | 0.093 |
|
K. pneumoniae kp-Mo-7 |
64 (64) | 16 (16) | 2 (2) | 2 (2) | 0.156 | 2 (2) | 1 (1) | 0.092 | 1 (1) | 0.5 (0.5) | 0.062 |
|
P. aeruginosa RP73 |
32 (32) | 64 (64) | 8 (16) | 4 (4) | 0.31 | 4 (8) | 8 (8) | 0.25 | 4 (4) | 1 (1) | 0.14 |
|
P. aeruginosa PAO1 |
16 (16) | 64 (128) | 16 (32) | 2 (2) | 1.03 | 4 (4) | 2 (2) | 0.28 | 4 (4) | 0.5 (0.5) | 0.25 |
|
P. aeruginosa PA14 |
16 (32) | 64 (64) | 4 (8) | 4 (4) | 0.31 | 4 (4) | 4 (4) | 0.31 | 4 (4) | 1 (1) | 0.26 |
|
P. aeruginosa PA-Na-1 |
32 (64) | 64 (128) | 8 (8) | 2 (2) | 0.28 | 4 (4) | 2 (2) | 0.156 | 4 (4) | 0.5 (0.5) | 0.132 |
|
S. enterica ATCC 13076 |
4 (4) | 16 (32) | 1 (1) | 1 (1) | 0.312 | 1 (1) | 1 (1) | 0.312 | 0.5 (0.5) | 0.5 (0.5) | 0.15 |
|
S. maltophilia K279 |
128 (128) | 16 (16) | 16 (32) | 8 (8) | 0.62 | 4 (4) | 4 (8) | 0.281 | 4 (4) | 2 (2) | 0.156 |
|
E. faecalis ATCC 29212 |
32 (32) | 4 (8) | 4 (4) | 2 (2) | 0.625 | 0.5 (0.5) | 0.5 (0.5) | 0.14 | 0.5 (0.5) | 0.5 (0.5) | 0.14 |
|
E. faecium ATCC 6057 |
8 (8) | 4 (4) | 0.125 (0.125) | 0.5 (0.5) | 0.14 | 0.5 (0.5) | 0.125 (0.125) | 0.093 | 0.25 (0.25) | 0.06 (0.06) | 0.046 |
|
S. aureus ATCC43300 |
1 (2) | 8 (16) | 0.125 (0.125) | 0.5 (0.5) | 0.187 | 0.25 (0.25) | 0.06 (0.06) | 0.257 | 0.125 (0.125) | 0.25 (0.25) | 0.156 |
|
C. albicans ATCC 10231 |
16 (32) | 4 (4) | 8 (8) | 1 (1) | 0.75 | 2 (4) | 0.125 (0.125) | 0.156 | 2 (2) | 0.125 (0.0125) | 0.156 |
|
C. albicans 62033 |
16 (16) | 2 (2) | 8 (16) | 2 (2) | 1 | 4 (4) | 2 (2) | 0.75 | 4 (4) | 2 (2) | 0.75 |
|
C. parapsilosis 4609 |
64 (64) | 2 (2) | 8 (16) | 2 (2) | 0.51 | 1 (1) | 2 (2) | 0.26 | 1 (1) | 2 (2) | 0.26 |
* FIC index, Fractional Inhibitory Concentration index; (a) Σ FIC = [(MIC CHX + BZK) + 0 RV/MIC CHX] + [(MIC BZK + CHX) + 0 RV/MIC BZK]; (b) Σ FIC = [(MIC CHX + BZK) + 32 RV/MIC CHX] + [(MIC BZK + CHX) + 32 RV/MIC BZK]; (c) Σ FIC = [(MIC CHX + BZK) + 64 RV/MIC CHX] + [(MIC BZK + CHX) + 64 RV/MIC BZK]. The numbers outside and within the brackets indicate MIC and MBC or MCF values, respectively, and are expressed in mg/L. The numbers 0, 32 and 64 indicate RV concentrations and are expressed in mg/L.