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. 2022 Jul 19;11(7):1399. doi: 10.3390/antiox11071399

Figure 9.

Figure 9

Cytoprotection of TXNRD1 overexpression against hypoxia-induced cell death in HKC-8 cells. Both HKC-8Control and HKC-8TXNRD1 cells in 24-well plates were incubated in an atmosphere containing 1% O2 (hypoxia) or 20% O2 (normoxia) in the absence (medium) or presence of 100 µM catechin for 72 h. Cell death was measured using FACS analysis. (A) Typical FACS graphs showing the dead cell populations (Q1–Q3), (B) Data are presented as mean ± SD of four measurements of total cell death and are representative of three separate experiments. * p < 0.0001 (hypoxic HKC-8TXNRD1 vs. hypoxic HKC-8Control in Medium, two-tailed t-test, n = 4), ** p = 0.0001 (hypoxic HKC-8TXNRD1 vs. hypoxic HKC-8Control in the presence of catechin, two-tailed t-test, n = 4).