Table 1.
Molecular functions activated with strength > 1 in hypoxic HKC-8 cells.
| GO-Term | Description of Functions | Count in Network | Strength | False Discovery Rate |
|---|---|---|---|---|
| 0004666 | Prostaglandin-endoperoxide synthase activity | 2 (PTGS1, PTGS2) of 2 | 2.83 | 0.0032 |
| 0004357 | Glutamate-cysteine ligase activity | 2 (GCLC, GCLM) of 2 | 2.83 | 0.0032 |
| 0016175 | Superoxide-generating NAD(P)H oxidase activity | 5 (NCF2, DUOX2, NOX4, NOX5, CYBB) of 11 | 2.49 | 3.54 × 10−8 |
| 0016174 | NAD(P)H oxidase H2O2-forming activity | 2 (DUOX2, NOX4) of 9 | 2.18 | 0.0197 |
| 0004601 | Peroxidase activity | 5 (PTGS1, PTGS2, DUOX2, GPX2, CYGB) of 41 | 1.92 | 3.00 × 10−6 |
| 0016209 | Antioxidant activity | 7 (PTGS1, PTGS2, DUOX2, GPX2, TXNRD1, SRXN1, CYGB) of 74 | 1.8 | 3.54 × 10−8 |
| 0050660 | Flavin adenine dinucleotide binding | 5 (NOX4, NOX5, CYBB, TXNRD1, DHCR24) of 82 | 1.61 | 4.94 × 10−5 |
| 0016651 | Oxidoreductase activity, acting on NAD(P)H | 6 (NCF2, DUOX2, NOX4, NOX5, CYBB, TXNRD1) of 107 | 1.58 | 4.93 × 10−6 |
| 0009055 | Electron transfer activity | 4 (NCF2, NOX4, GPX2, TXNRD1) of 103 | 1.42 | 0.0039 |
| 0016491 | Oxidoreductase activity | 13 (PTGS1, PTGS2, ALOX12, NCF2, DUOX2, NOX4, NOX5, CYBB, GPX2, TXNRD1, SRXN1, CYGB, DHCR24) of 726 | 1.08 | 3.54 × 10−8 |