Table 2.
Molecular functions activated with strength > 1 by catechin in hypoxic HKC-8 cells.
| GO-Term | Description of Functions | Count in Network | Strength | False Discovery Rate |
|---|---|---|---|---|
| 0008379 | Thioredoxin peroxidase activity | 2 (PRDX3, PRDX4) of 5 | 2.75 | 0.0036 |
| 0016175 | Superoxide-generating NAD(P)H oxidase activity | 4 (NCF1, NCF2, NOX5, CYBB) of 11 | 2.71 | 1.80 × 10−7 |
| 0016176 | Superoxide-generating NADPH oxidase activator activity | 2 (NCF1. NCF2) of 9 | 2.49 | 0.0070 |
| 0016668 | Oxidoreductase activity, acting on a sulfur group of donors | 2 (TXNRD1, PRDX3) of 12 | 2.37 | 0.0099 |
| 0016209 | Antioxidant activity | 6 (PRDX4, TXNRD1, SRXN1, PRDX3, SOD3, PTGS2) of 74 | 2.05 | 1.82 × 10−8 |
| 0004601 | Peroxidase activity | 3 (PRDX3, PRDX4, PTGS2) of 41 | 2.01 | 0.0018 |
| 0016651 | Oxidoreductase activity, acting on NAD(P)H | 6 (TXNRD1, PRDX3, NCF1, NCF2, NOX5, CYBB) of 107 | 1.89 | 1.01 × 10−7 |
| 0016667 | Oxidoreductase activity, acting on a sulfur group of donors | 3 (TXNRD1, PRDX3, SRXN1) of 59 | 1.85 | 0.0036 |
| 0050660 | Flavin adenine dinucleotide binding | 3 (TXNRD1, CYBB, NOX5) of 82 | 1.71 | 0.0070 |
| 0009055 | Electron transfer activity | 3 (TXNRD1, NCF1, NCF2) of 103 | 1.61 | 0.0116 |
| 0016491 | Oxidoreductase activity | 10 (TXNRD1, PRDX3, PRDX4, SRXN1, SOD3, NOX5, NCF1, NCF2, CYBB, PTGS2) of 726 | 1.28 | 1.50 × 10−8 |
Data were generated using STRIP database software (version 11.5, string-db.org, accessed on 23 March 2022; ELIXIR, Hinxton, Cambridgeshire, UK).