Figure 1.

Approaches to patient matchmaking. (a) Two‐sided matchmaking: parties flag the same candidate gene and subsequently exchange more detailed information related to patient phenotypes and DNA variation to resolve possible matches. (b) One‐sided matchmaking: one party flags a candidate gene and queries a database of genomic variation to examine DNA variants present in the data along with phenotypic and inheritance information to identify matches. (c) Zero‐sided matchmaking: automated computational approaches compare patient phenotypes and genotypes within or between databases to identify matches