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. 2022 Jun 28;11(7):975. doi: 10.3390/biology11070975

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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miR-133b could be a regulator of EIF4A1 in LUAD. We investigated the epigenetic regulatory mechanisms in terms of DNA methylation with regards to correlation and copy number variation. The low expression levels of EIF4A1 methylation in tumor tissues compared with normal ones (A) and its negative correlation (B). The expression correlation between DNA copy number and EIF4A1 (C). In addition, tissue levels of the predicted miRNAs (miR-133b, miR-142 and miR-212) of EIF4A1 from TargetScan in normal vs. tumor tissues (D). The correlations between the predicted miRNAs and EIF4A1 (E), and hsa-miR-133b expression correlated with stages (F). The predicted binding sites of miR-133b in the 3′UTR of EIF4A1 mRNA and its context++ score (G). ***: p < 0.005.