Table 2.
Overview of novel potential therapeutic drugs that directly target the molecular pathways responsible for ROS generation.
| Molecule | Target | Model | Effect | References |
|---|---|---|---|---|
| Vitamin E | ROS | NASH | protection of structural components of cell membrane from peroxidation | [127] |
| Silibin | ROS | ALD | increased of GSH concentration | [128] |
| Chlormethiazole | CYP2E1 | ALD | reduction of proteasome proteolytic enzyme activity induced by ethanol | [129] |
| Nrf2 activators | Nrf2 | NAFLD/NASH | prevention of inflammation, trygliceride accumulation | [130,131] |
| Ethyl pyruvate | Nrf2 | ALD | increase of anti-inflammatory factors | [132] |
| MCC950 | NLPR3 | NASH | decrease of AST and ALT and liver inflammation | [133,134] |