Table 5.
Minerals as modulators of OS-induced senescence.
| Mineral | Sample | Treatment/Condition | Result | Ref. |
|---|---|---|---|---|
| Zinc | Colon cancer lines SW480 and SW620 | ↓ Zinc | ↑ Oxidative stress, cellular proliferation, stress signalling morphological changes, cell death | [409] |
| Zinc | Dermal fibroblast | ↑ Zinc | ↑ Oxidative stress and DNA damage | [410] |
| Zinc | HCAECs | ↑ Zinc | ↑ Senescence | [411] |
| Selenium | Bone marrow stromal cells | ↑ Selenium | ↓ Senescence | [412] |
| Selenium | Keratinocytes | ↑ Selenium | ↓ Senescence | [413] |
| Selenium | Human fibroblasts | ↑ Selenium | ↓ Senescence | [414] |
| Selenium | Mice | ↓ Selenium | ↑ Senescence | [415] |
| Magnesium | Endothelial cells | ↓ Magnesium | ↑ Oxidative stress and cell death | [416] |
| Magnesium | Endothelial cells | ↓ Magnesium | ↑ Pro-inflammatory molecules | [417] |
| Magnesium | Embryo-hepatocytes | ↓ Magnesium | ↑ Oxidative stress | [418] |
| Magnesium | Human fibroblasts | ↓ Magnesium | ↑ Telomere shortening | [419] |
| Magnesium | Rats | ↓ Magnesium | ↑ Age-related diseases | [420] |
Abbreviations: HCAECs: Human coronary artery endothelial cells; ↑: increase; ↓: decrease.