Table 6.
Interplay between zinc-finger proteins and senescence.
| Mineral | Sample | Zinc-Finger Proteins | Ref. |
|---|---|---|---|
| Zinc | Endothelial cells | PATZ1 is downregulated in senescence | [430] |
| Zinc | Mesenchymal stem cells | ZKSCAN3 upregulation contrast senescence | [431] |
| Zinc | Human diploid fibroblast | ZHX3 is downregulated in senescence | [432] |
| Zinc | Mouse embryonic fibroblasts | KLF4 reduces cellular senescence and DNA damage | [433] |
| Zinc | NIH3T3 and C2C12 cells | ZFP637 protects from oxidative stress | [434] |
| Zinc | Hepatic stellate cells | ZEB2 protects from oxidative stress and senescence | [435] |
| Zinc | Dermal fibroblasts | ZEB1 protects from oxidative stress and senescence | [436] |
| Zinc | Cell lines (A549, NCI-H441 and NCI-H460, 293T) | ZNF768 depletion induces senescence | [437] |
Abbreviations: KLF4: Kruppel-like factor 4; PATZ1: POZ/BTB and AT-hook-containing zinc finger protein 1; ZEB1: zinc finger E-box-binding homeobox 2; ZEB2: zinc finger E-box-binding homeobox 2; ZFP637: zinc finger protein 637; ZHX3: zinc fingers and homeoboxes 3; ZKSCAN3: zinc finger with KRAB and SCAN domains 3; ZNF768: zinc finger protein 768.