Table 1.

Changes in anthropometric and biochemical characteristics of adults with nonalcoholic fatty liver disease (NAFLD) categorized by tertiles after 6 months of lifestyle intervention in intrahepatic fat content (IFC).

		Tertile 1 (<−0.567) n = 20	Tertile 2 (−0.567 to −7.13) n = 20	Tertile 3 (>−7.13) n = 20	p-Value
Weight (kg)	Baseline	91.5 ± 15.7	97.8 ± 16.2	93.9 ± 8.1
	6 months	90.4 ± 14.9	92.7 ± 13.2	87.1 ± 8.53
	$\mathsf{\Delta }$	−1.06 ± 3.36	−5.08 ± 4.83 *	−6.79 ± 5.06 *	<0.001
BMI (kg/m2)	Baseline	32.5 ± 3.30	34.4 ± 4.93	34.0 ± 2.70
	6 months	32.2 ± 2.91	32.7 ± 4.48	31.5 ± 2.29
	$\mathsf{\Delta }$	−0.375 ± 1.17	−1.71 ± 1.56 *	−2.51 ± 1.87 *	<0.001
Systolic blood pressure (mmHg)	Baseline	137.4 ± 20.5	134.0 ± 12.2	142.2 ± 16.9
	6 months	134.0 ± 12.0	135.5 ± 11.1	132.7 ± 11.0
	$\mathsf{\Delta }$	−3.74 ± 12.6	1.56 ± 13.1	−1.99 ± 30.4	0.318
Diastolic blood pressure (mmHg)	Baseline	80.8 ± 9.71	81.5 ± 7.03	84.3 ± 9.98
	6 months	81.4 ± 7.55	82.0 ± 7.65	78.0 ± 9.05
	$\mathsf{\Delta }$	0.031 ± 9.76	1.00 ± 6.83	−0.353 ± 18.4	0.155
Glucose (mg/dL)	Baseline	109.2 ± 23.5	116.1 ± 41.9	115.1 ± 20.4
	6 months	110.1 ± 25.7	112.5 ± 43.7	111.7 ± 41.0
	$\mathsf{\Delta }$	0.850 ± 17.9	−2.76 ± 11.0	−3.40 ± 27.7	0.253
Hb1Ac (%)	Baseline	6.09 ± 1.08	6.08 ± 1.13	6.00 ± 0.557
	6 months	6.05 ± 0.886	5.85 ± 0.880	5.74 ± 0.412
	$\mathsf{\Delta }$	−0.026 ± 0.456	−0.229 ± 0.384	−0.238 ± 0.447	0.235
Triglycerides (mg/dL)	Baseline	178.3 ± 81.8	163.0 ± 58.5	240.2 ± 140.6
	6 months	232.2 ± 160.5	128.1 ± 34.2	159.4 ± 78.5
	$\mathsf{\Delta }$	53.8 ± 159.7	−46.8 ± 34.1 *	−80.8 ± 145.5 *	0.002
HDL cholesterol (mg/dL)	Baseline	44.1 ± 11.9	42.2 ± 8.28	39.6 ± 6.94
	6 months	44.7 ± 14.0	45.8 ± 10.9	39.9 ± 5.83
	$\mathsf{\Delta }$	0.950 ± 6.59	4.24 ± 5.25	0.250 ± 4.51	0.054
LDL cholesterol (mg/dL)	Baseline	127.3 ± 34.5	125.2 ± 27.2	129.0 ± 28.8
	6 months	128.5 ± 35.1	112.4 ± 25.8	121.6 ± 33.4
	$\mathsf{\Delta }$	5.88 ± 33.8	−7.38 ± 25.0	−7.11 ± 21.3	0.266
Cholesterol total (mg/dL)	Baseline	224.0 ± 74.7	200.6 ± 32.1	214.8 ± 34.1
	6 months	212.7 ± 38.5	183.6 ± 33.1	192.9 ± 39.2
	$\mathsf{\Delta }$	−6.05 ± 78.9	−11.1 ± 26.1	−21.9 ± 35.5	0.616
Bilirubin (mg/dL)	Baseline	0.811 ± 0.527	0.650 ± 0.254	0.700 ± 0.395
	6 months	0.739 ± 0.379	0.636 ± 0.267	0.820 ± 0.554
	$\mathsf{\Delta }$	0.024 ± 0.371	0.003 ± 0.223	0.109 ± 0.300	0.516
AST (U/L)	Baseline	23.3 ± 8.33	22.8 ± 5.71	29.4 ± 10.6
	6 months	23.9 ± 6.40	20.9 ± 5.52	23.9 ± 7.68
	$\mathsf{\Delta }$	0.550 ± 6.42	−1.11 ± 7.83	−3.28 ± 7.12	0.246
ALT (U/L)	Baseline	27.9 ± 10.1	32.4 ± 19.1	60.8 ± 58.7
	6 months	28.7 ± 11.9	24.0 ± 9.35	29.8 ± 13.0
	$\mathsf{\Delta }$	−0.800 ± 8.46	−8.48 ± 15.4	−28.0 ± 50.8 *	0.004
GGT (U/L)	Baseline	44.2 ± 29.2	32.5 ± 14.3	48.8 ± 25.2
	6 months	43.8 ± 23.8	27.8 ± 11.3	44.7 ± 55.5
	$\mathsf{\Delta }$	−0.450 ± 19.5	−4.68 ± 5.71	−4.14 ± 40.4	0.022
CRP (mg/dL)	Baseline	0.498 ± 0.505	0.529 ± 0.509	0.529 ± 0.711
	6 months	0.356 ± 0.394	0.435 ± 0.336	0.322 ± 0.272
	$\mathsf{\Delta }$	−0.143 ± 0.494	−0.090 ± 0.318	−0.220 ± 0.749	0.750

Values are the mean ± SD. Abbreviations: BMI, body mass index; Hb1Ac, glycated hemoglobin 1A; HDL cholesterol, high-density lipoprotein; LDL cholesterol, low-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transferase; CRP, c-reactive protein. Difference in means of IFC classified in tertiles was tested with one-factor ANOVA and Bonferroni’s post hoc analysis when variables followed a normal distribution or with Kruskal–Wallis test for non-normally distributed variables. * Difference with respect to tertile 1.