OA	Osteoarthritis
AGEs	Advanced glycation end products
AMPK	AMP-activated protein kinase
ATP	Adenosine-triphosphate
ATR	Ataxia-telangiectasia mutated and rad3-related
ATRIP	ATR-interacting protein
CDK	Cyclin-dependent kinase
CR	Caloric restriction
DAMPs	Damage-associated molecular patterns
DMOADs	Disease-modifying OA drugs
ECM	Extracellular matrix
eIF	Eukaryotic initiation factor
ER	Endoplasmic reticulum
ERK	Extracellular regulated protein kinases
FOXO	Forkhead box O
GAG	Glycosaminoglycan
HSF	Heat shock factor
IGF	Insulin-like growth factor
IIS	Insulin/IGF-1 signaling
IL	Interleukin
LINE-1	Long interspersed nuclear element 1
MAPK	Mitogen-activated protein kinase
MMPs	Matrix metalloproteinases
MSC	Mesenchymal stem cell
mtDNA	Mitochondrial DNA
NAD	Nicotinamide adenine dinucleotide
ncRNAs	Non-coding RNAs
Nrf2	Nuclear factor-erythroid 2-related factor
PRR	Pathogen-recognition receptors
ROS	Reactive oxygen species
RS	Replicative senescence
RUNX2	Runt-related transcription factor 2
SASPs	Senescence-associated secretory phenotypes
SA-β-gal	Senescence-associated-β-galactosidase
SIPS	Stress-induced premature senescence
SIRT	Sirtuin
SOD	Superoxide dismutase
SPD	Spermidine
SQST	Sequestosome
TGF-β	Transforming growth factor-β
TLR	Toll-like receptors
TOR	Target of rapamycin