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. 2022 Jun 24;11(7):1238. doi: 10.3390/antiox11071238

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Uridine reduced the OA-induced accumulation of lipid droplets in the primary hepatocytes of Nile tilapia. (a) The proliferation of cells that are analyzed by CCK-8 in oleic acid (OA)-induced cell model (n = 10). (b) The contents of TG in the hepatocytes (n = 6). (c) Lipid droplets staining with BODIPY 493/503 in the hepatocytes. Scale bar, 100 µm (n = 6). (d,e) Gene expression of lipid synthesis (d) and catabolism (e) in the hepatocytes (n = 6). Statistics were analyzed by one-way ANOVA with Tukey’s adjustment and presented as mean ± SEM (*, p < 0.05; **, p < 0.01; ***, p < 0.001).