Table 5.
Assay of cytokines on Day 14 after admission with MIS-C manifestations.
| Variable | Group A (Mild) (n = 33) Median (IQR) |
Group B (Severe) (n = 27) Median (IQR) |
p Value # |
|---|---|---|---|
|
Interferon alpha (IFN-α) (reference, <2 U/mL) |
1.1 (0.8–4.9) | 2 (0.5–12) | 0.4666 |
|
Interferon gamma (IFN-γ) (reference, 0.10–18.00 pg/mL) |
0.66 (0.11–1.57) | 0.58 (0.11–1.69) | 0.9791 |
|
Interleukin 1 beta (IL-1β) (reference, 0.5–12 pg/mL) |
8 (5–14) | 16 (5–21.5) | 0.0033 # |
|
Interleukin 6 (IL-6) (reference, <5 pg/mL) |
9 (8–32) | 13 (9–39) | 0.0033 # |
|
Interleukin 8 (IL-8) (reference, 2.8–17.0 pg/mL) |
6.8 (2.5–14.6) | 4.7 (2–16) | 0.5194 |
|
Interleukin 10 (IL-10) (reference, <10 pg/mL) |
3.82 (2.17–7.27) | 5.23 (3.31–10.64) | 0.425 |
|
Tumor necrosis factor alpha (TNF-α) (reference, <8.5 pg/mL) |
13.5 (8.2–21.4) | 15 (8.1–30) | 0.5194 |
|
Granulocyte colony stimulating factor (G-CSF) (reference, 5–42 ng/L) |
24.3 (7.9–34) | 33.5 (21.3–48) | 0.0508 |
|
Granulocyte-macrophage colony-stimulating factor (GM-CSF) (reference, 0–0.39 pg/mL) |
0.45 (0.1–1.2) | 0.9 (0.3–2.5) | 0.0336 # |
|
high-mobility group box 1 (HMGB1) (reference, 0.2–0.4 ng/mL) |
0.3 (0.1–1.4) | 0.3 (0.2–1.3) | 0.9935 |
|
Human C-X-C motif chemokine ligand 10 (CXCL10) (reference, <7.8 pg/mL) |
3.8 (1.2–8) | 5.9 (4.7–10.3) | 0.9924 |
# p < 0.05 statistically significant difference between the mild and severe groups (Mann–Whitney U test for the median and inter quartile range).