Figure 3.
Effects of the co-administration of a CO-releasing molecule and an HO-1 inducer with two H2S donors on MIA-induced mechanical allodynia and loss of grip strength. The mechanical antiallodynic effects (A) and the recovery of grip strength (B) induced by the acute intraperitoneal administration of 5 mg/kg of CORM-2, 0.5 mg/kg of CoPP, 3 mg/kg of DADS, or 0.4 mg/kg of GYY4137 administered alone or combined are displayed. For each test, * denotes significant differences vs. vehicle plus vehicle-treated mice; + vs. CORM-2 or CoPP plus vehicle-treated mice and # vs. vehicle plus DADS- or GYY4137-treated mice (p < 0.05; one-way ANOVA, followed by the Student–Newman–Keuls test). Data are expressed as the mean values of the maximal possible effect (%) for the mechanical allodynia and the recovery in grip strength (%) ± SEM; n = 6 animals per dose and treatment.