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. 2022 Jun 27;11(7):1271. doi: 10.3390/antiox11071271

Figure 4.

Figure 4

Effects of the co-administration of DADS and GYY4137 with vehicle, ML-385, SnPP or dicoumarol in the mechanical allodynia and loss of grip strength caused by MIA. The antiallodynic (A,C) and the recovery of grip strength (B,D) induced by DADS (30 mg/kg) or GYY4137 (6 mg/kg) combined with 25 mg/kg of ML-385 or 10 mg/kg of SnPP or dicoumarol (DICO) are shown. The effects produced by each of these treatments administered alone are also represented. For each treatment and test assessed, @ denotes significant differences vs. the other groups (p < 0.05, one-way ANOVA; Student–Newman–Keuls test). Data are expressed as mean values of the maximal possible effect (%) for the mechanical allodynia and the recovery of grip strength (%) ± SEM; n = 6 animals per dose and treatment.