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. 2022 Jun 27;11(7):1271. doi: 10.3390/antiox11071271

Figure 6.

Figure 6

Effects of treatment with DADS and GYY4137 on the Nrf2, HO-1, NQO1, SOD-1, and GSTM1 protein levels in the PAG of MIA-injected mice. The expression of Nrf2 (A), HO-1 (B), NQO1 (C), SOD-1 (D), and GSTM1 (E) in PAG of MIA-injected animals treated with vehicle (MIA-VEHI), DADS (MIA-DADS) or GYY4137 (MIA-GYY4137) and of SS-injected mice treated with vehicle (SS-VEHI) are represented. All proteins are expressed relative to GAPDH levels. For each protein, * indicates significant differences vs. SS plus vehicle-treated mice; + vs. MIA plus vehicle-treated animals; # vs. MIA plus DADS-treated mice and $ vs. MIA plus GYY4137-injected mice (p < 0.05, one-way ANOVA; Student–Newman–Keuls test). Examples of blots for Nrf2, HO-1, NQO1, SOD-1, GSTM1, and GAPDH are shown (F). Results are displayed as the mean ± SEM (n = 3 samples).