Table 1.

Experimental selected protocols of antibacterial high-dose nitric oxide delivery.

Study	Model	Dose	Treatment Protocol	Year
Ghaffari et al. [13]	in vitro	160–200 ppm	Continuous 48 h	2005
McMullin et al. [55]	in vitro	200 ppm	Continuous 5 h	2005
Miller et al. [56]	in vitro	160–200 ppm	Intermittently 30 min every 3.5 h and Continuous for up to 24 h	2009
Miller et al. [66]	in vivo animal model	160 ppm	Intermittently 30 min every 4 h	2013
Wiegand S. et al. [67]	in vivo animal model	160/200 ppm 300 ppm	Continuous (48 h) Intermittent 12 min, every 3 h for 48 h	2021
Miller et al. [69]	Clinical Study	160 ppm	Intermittently 30 min every 3.5 h, 5 times daily	2012
Deppish et al. [70]	Clinical Study	160 ppm	Intermittently 30 min, 3 times daily of 5 days	2016
Yaacoby-Bianu et al. [74]	Compassionate	160 ppm	Intermittently Minimal time interval 3.5 h (max 21 days)	2018
Bentur et al. [71]	Pilot Clinical Study	160 ppm	Intermittently 30 min, 5 times daily for 14 days and 3 times daily for 7 days	2020
Bartley et al. [75]	Clinical Study	160 ppm	Intermittent over a 28-days	2020
Bogdanovski et al. [72]	Compassionate	up to 240 ppm	Intermittently two courses 5 times daily for 5 days and 3 times daily for 8 days	2020
Goldbart et al. [76]	RCT	160 ppm	Intermittently 30 min, 5 times daily of 5 days	2020
Goldbart et al. [73]	Compassionate	150–250 ppm	Intermittent 4 times a day for 2 weeks, 2 times a day 2 weeks and one in the last day of treatment. (29-day treatment course)	2021