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. 2022 Jul 18;10(7):1731. doi: 10.3390/biomedicines10071731

Figure 2.

Figure 2

Inhibitory effect of DIZE and candesartan during AngII-induced vasoconstriction responses in rabbit iliac arteries. To determine the ability of DIZE to inhibit the vasoconstriction responses to cumulative doses of AngII, the iliac rings were incubated with DIZE and compared to the candesartan and control rings. As expected, incubation with candesartan, a known ARB, potently inhibited the vasoconstriction responses to AngII at doses AngII (10−9.0 M) to AngII (10−6.5 M) (mean ± SEM is shown, the significance presented in Table 1). Similar results were observed in rings incubated with DIZE at doses AngII (10−9.0 M) to AngII (10−6.5 M) (mean ± SEM is shown, the significance presented in Table 1).