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The genomic molecular pathway by ATRA. In the absence of ligands, retinoic acid X receptors and RXR/RAR heterodimers bind to RAREs in the regulatory regions of target genes and inhibit transcription by recruiting HDAC or silencing mediators (SMRT and NCoR). After binding to ATRA, the corepressor complex is dissociated, and the coactivator binds to histone acetyltransferase (HAT) activity, resulting in transcriptional activation of target genes.
