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. 2022 Jun 28;10(7):1531. doi: 10.3390/biomedicines10071531

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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USP6NL is markedly expressed in TMZ resistant cells with high stemness phenotypes (A–C) Representative image of colony-forming (self-renewal ability), tumor initiation (sphere assay), and migratory/invasive properties of TMZ-resistant GBM cells (U87MG-R and T98G-R). Scale bar: 100 μm. (D,E) Western blot and qRT-PCR results of the expression of USP6NL and key CSC’s markers associated with therapy resistance. (F) EMT processes in TMZ-resistant GBM (U87MG-R and T98G-R) cells were also examined through IF analysis of E-cadherin and N-cadherin staining. Scale bar: 10 μm. *** p < 0.001.

USP6NL is markedly expressed in TMZ resistant cells with high stemness phenotypes (A–C) Representative image of colony-forming (self-renewal ability), tumor initiation (sphere assay), and migratory/invasive properties of TMZ-resistant GBM cells (U87MG-R and T98G-R). Scale bar: 100 μm. (D,E) Western blot and qRT-PCR results of the expression of USP6NL and key CSC’s markers associated with therapy resistance. (F) EMT processes in TMZ-resistant GBM (U87MG-R and T98G-R) cells were also examined through IF analysis of E-cadherin and N-cadherin staining. Scale bar: 10 μm. *** p < 0.001.