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. 2022 Jun 28;10(7):1531. doi: 10.3390/biomedicines10071531

Figure 5.

Figure 5

USP6NL regulates the DNA damage response. (A) Bioinformatics analysis of the correlation expression of USP6NL and EGFR (r2 = 0.177), with DNA repair response (DDR) markers RAD51 (r2 = 0.202) and BRCA2 (r2 = 0.282). (B,C) Immunostaining with indicated antibodies. The representative image shows that USP6NL depletion inhibits DNA damage repair by inhibiting the expression of RAD51 and BRCA2-positive cells; scale bar: 10 μm (D) Representative images of RAD51/BRCA2 foci in USP6NL-knockdown cells. * p < 0.05, ** p < 0.01 and *** p < 0.001.