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. 2022 Jun 28;10(7):1531. doi: 10.3390/biomedicines10071531

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of USP6NL inhibition on the expression of autophagy markers in GBM cells. (A) Bioinformatics analysis of the correlation expression of USP6NL and EGFR with autophagic markers ATG5, ATG7, Beclin-1, and LC3A/B. (B,C) Immunofluorescence image and Western blot analysis of the expression of autophagic markers after USP6NL inhibition and TMZ treatment. Scale bar: 10 μm (D–F) Coimmunoprecipitation to demonstrate the association of USP6NL with EGFR and the regulation of EGFR ubiquitination, with or without USP6NL. * p < 0.05, *** p < 0.001.