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USP6NL-knockdown suppressed tumorigenicity of T98G GBM cells in nude mice. (A) Time course of control and shUSP6NL tumor volume progression, as measured using a caliper. (B) The effect of USP6NL-knockdown or TMZ treatment on the weights of tumor-bearing mice. (C) Apoptosis analysis in the tumor cells (day 22) by using the TUNEL assay (×200). *** p < 0.001 vs. Control.
