Figure 6.

Scatter plots of binding affinity and logS for various weights of sequences designed in AfDesign using three solubility indices. Each point shows the binding affinity and logS of a sequence designed in AfDesign with a weight of 0.5 using the Hydrophobicity Index (a), Hydropathy Index (b), and Solubility-Weighted Index (SWI) (c) as solubility indices in the loss function. Gray dots show the binding affinity and logS of sequences designed in AfDesign without a solubility index. The horizontal dashed line shows the average binding affinity of the p53 peptide. The vertical dashed line shows the logS values for the p53 peptide.