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Functional activities of mBDNF and pro-BDNF in the white adipose tissue. The mBDNF and pro-BDNF are mainly synthesized by the progenitor cells and macrophages, which act on the mature adipocyte to modulate its metabolism. The BDNFs might also act as an autocrine to modulate the differentiation of pre-adipocytes and the transformation of macrophages.
