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Functional activities of BDNF in skeletal muscle (Skm). In Skm, mBDNF is produced by the myofiber, satellite cells, and blood vessel endothelial cells. It acts in an autocrine and paracrine manner to modulate the mitochondrial dynamics and lipid metabolism in myofibers, control the myogenesis, and maintain the functions of the neuromuscular junction. The myofiber-generated BDNF is also secreted into circulation to regulate the functions of the pancreas.
